Seven years after vanishing from the public eye, Earl Stone (Clint Eastwood) is presumed dead β until a DEA task force intercepts encrypted cartel chatter about “El Gringo Viejo,” a legendary mule who once betrayed the Sinaloa. Now living under a new name in the heart of Texas ranchland, Earl is dragged back into the drug world when his estranged granddaughter is kidnapped in a cartel revenge plot targeting his bloodline. No longer just a courier, Earl must become a hunter.
Haunted by past choices and driven by newfound purpose, Earl partners with a reformed ex-agent (played by Josh Brolin), forming an unlikely alliance between two men whoβve seen too much. As they journey through the borderlands, unraveling a deadly network of betrayal and shifting power, Earl finds himself at the center of a war between rival cartels β each wanting him either dead or silenced forever.
Meanwhile, the DEA has reactivated Agent Colin Bates (Bradley Cooper), whose obsession with Earl never truly faded. As Bates closes in, questions arise: is Earl back to settle old debts, or is he hiding a final play that could dismantle the cartel empire once and for all? Every stop along the highway brings ghosts, danger, and the looming specter of justice β or damnation.
The Mule 2 (2025) is a gritty, emotionally charged neo-Western about legacy, redemption, and the price of walking away clean. In the twilight of his life, Earl Stone has one last delivery to make β and this time, it’s personal.